Amide nitrogen pyramidalization changes lactam amide spinning
نویسندگان
چکیده
منابع مشابه
The Amide Nitrogen of Blood.
Certain chemical changes are known to occur in muscle during, and immediately following, short periods of exercise. With respect to the alteration in the acid-base equilibrium under such conditions, some facts are definitely established. It has been shown by Barr and Himwich (1) that within a few minutes after exercise very considerable, amounts of plasma bicarbonate are neutralized by acid, an...
متن کاملMeasuring amide nitrogen quadrupolar coupling by high-resolution 14N/13C NMR correlation under magic-angle spinning.
The measurement of amide nitrogen 14N quadrupolar coupling by two-dimensional 14N/13C correlation experiment is presented with a natural abundant polypeptide. Directly bonded 14N/13C pairs are correlated through J and residual dipolar coupling under magic-angle spinning using a HMQC-type pulse sequence. The 14N quadrupolar coupling is measured from the isotropic second-order quadrupolar shift o...
متن کاملAmide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability.
Amide-amide hydrogen bonds have been implicated in directing protein folding and enhancing protein stability. Inversion transfer (13)C NMR spectroscopy and IR spectroscopy were used to compare the ability of various amide solvents and of water to alter the rate of the cis-trans isomerization of the prolyl peptide bond of Ac-Gly-[β,δ-(13)C]Pro-OMe and the amide I vibrational mode of [(13)C=O]Ac-...
متن کاملStrong Hydrogen Bonding to the Amide Nitrogen Atom in an "Amide Proton Sponge": Consequences for Structure and Reactivity
The carbonyl oxygen atom of the amide functional group is universally believed to be the thermodynamically preferred site of protonation in amides;[1] however, N protonation has been proposed to play a key role in biologically important reactions of peptides and proteins such as acid-catalyzed peptide hydrolysis[2] and cis ± trans isomerization about the CÿN bond.[3] Extensive research into the...
متن کاملAn amide cyclophane
The title compound, 8,18-dithia-2,6-diaza-13(1,4)-piperidina-1(1,2),4(1,3),7(1,2)-tribenzenaoctadecaphane-10,15-diyne-3,6-dione, C32H30N4O2S2, is composed of a relatively planar bis-(2-mercaptophen-yl)isophthalamide unit linked to a bridging 1,4-di(but-2-yn-1-yl)piperazine unit, forming a macrocycle. The isophthalamide ring is inclined to the outer mercaptophenyl rings by 8.18 (11) and 5.59 (10...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-018-08249-9